Neurological complexity in systemic lupus erythematosus: insights into autoimmune encephalitis
Neurological complexity of SLE
DOI:
https://doi.org/10.59747/smjidisurabaya.v1i1.34Kata Kunci:
Systemic lupus erythematosus, Autoimmune encephalitis, Autoantibody, ImmunologyAbstrak
Background: Autoimmune encephalitis (AE) is an inflammatory syndrome characterized by autoantibodies targeting the central nervous system (CNS), leading to a wide range of neurological and psychiatric manifestations. Objective: This systematic review aims to investigate the coexistence of AE and systemic lupus erythematosus (SLE) to shed light on potential underlying mechanisms. Materials and Methods: Following PRISMA guidelines, a comprehensive search was conducted using Boolean logic in research databases i.e., PubMed, ProQuest, ScienceDirect, and Web of Science to identify relevant studies on AE, SLE, and their potential correlation. After the initial screening, exclusion, and quality assessment using the Joanna Briggs Institute Critical Appraisal Checklist, 14 studies were included for analysis. Among 18 patients, 88.9% were female whose an average age was 31.9 ± 12.7 years. Clinical presentations were varied, including cognitive impairment (66.67%), seizures (61.1%), altered mental status (50%), and movement disorders. Neuroimaging and neurophysiological findings consistently aligned with encephalitis, with MRI abnormalities observed in 94.4% of cases. Various autoantibodies were identified, including anti-NMDAR, anti-AMPA-R2, and anti-GluR antibodies. Conclusion: The identification of neuronal antibodies is crucial, particularly in scenarios involving both neuropsychiatric SLE (NPSLE) and encephalitis. This investigation aims to reveal etiological insights. The ongoing debate revolves around whether SLE-related encephalitis is associated with NPSLE through SLE antibodies or involves distinct antibodies. Further clinical research is essential to clarify the pathogenic role of autoantibody in SLE-linked AE.
Referensi
Angst, D.B.M., de Figueiredo, N.S.V., Passarelli, V., Baldocchi, M.A., Rocha, M.S.G., Brucki, S.M.D., 2015. Autoimmune limbic encephalitis: A manifestation of systemic lupus erythematosus in the central nervous system. Dement. Neuropsychol.
Asmaa, T., Wafa, A., Chawad, W., Idrissi, F.I. El, Harmouche, H., Maamar, M., Khibri, H., Mezalek, Z.T., Adnaoui, M., 2022. PO.1.16 Limbic encephalitis: a rare complication of systemic lupus erythematosus. Lupus Sci. Med. 9, A31--A32.
Bendorius, M., Po, C., Muller, S., Jeltsch-David, H., 2018. From Systemic Inflammation to Neuroinflammation: The Case of Neurolupus. Int. J. Mol. Sci. 19, 3588.
Bravo-Zehnder, M., Toledo, E.M., Segovia-Miranda, F., Serrano, F.G., Benito, M.J., Metz, C., Retamal, C., Álvarez, A., Massardo, L., Inestrosa, N.C., González, A., 2015. Anti-Ribosomal P Protein Autoantibodies From Patients With Neuropsychiatric Lupus Impair Memory in Mice. Arthritis Rheumatol. 67, 204–214.
Buszman, P.E., Kiesz, S.R., Bochenek, A., Peszek-Przybyla, E., Szkrobka, I., Debinski, M., Bialkowska, B., Dudek, D., Gruszka, A., Zurakowski, A., Milewski, K., Wilczynski, M., Rzeszutko, L., Buszman, P., Szymszal, J., Martin, J.L., Tendera, M., 2008. Acute and Late Outcomes of Unprotected Left Main Stenting in Comparison With Surgical Revascularization. J. Am. Coll. Cardiol. 51, 538–545.
Dedhia, L., Pradhan, V., Ghosh, K., Nadkar, M., Parekh, S., 2018. Association of Human Leucocyte Antigen (HLA) class II with systemic lupus erythematosis (SLE) patients from western India. Meta Gene 16, 230–233.
Ellis, S.G., Hill, C.M., Lytle, B.W., 1998. Spectrum of surgical risk for left main coronary stenoses: Benchmark for potentially competing percutaneous therapies. Am. Heart J. 135, 335–338.
Gresa-Arribas, N., Titulaer, M.J., Torrents, A., Aguilar, E., McCracken, L., Leypoldt, F., Gleichman, A.J., Balice-Gordon, R., Rosenfeld, M.R., Lynch, D., Graus, F., Dalmau, J., 2014. Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: a retrospective study. Lancet Neurol. 13, 167–177.
Haghighi, A., Haza, S., 2010. Neuropsychiatric manifestations of systemic lupus erythematosus: Iranian experience. Ann. Indian Acad. Neurol. 13, 108.
Hanly, J.G., Kozora, E., Beyea, S.D., Birnbaum, J., 2019a. Review: Nervous System Disease in Systemic Lupus Erythematosus: Current Status and Future Directions. Arthritis Rheumatol. 71, 33–42.
Hanly, J.G., Kozora, E., Beyea, S.D., Birnbaum, J., 2019b. Nervous System Disease in Systemic Lupus Erythematosus: Current Status and Future Directions. Arthritis Rheumatol. 71, 33–42.
Hirohata, S., Arinuma, Y., Yanagida, T., Yoshio, T., 2014. Blood-brain barrier damages and intrathecal synthesis of anti-N-methyl-D-aspartate receptor NR2 antibodies in diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematosus. Arthritis Res. Ther. 16, R77.
Hirohata, S., Tanaka, K., 2019. Differential expression of antibodies to NMDA receptor in anti-NMDA receptor encephalitis and in neuropsychiatric systemic lupus erythematosus. Lupus Sci. Med. 6, e000359.
Holm, N.R., Mäkikallio, T., Lindsay, M.M., Spence, M.S., Erglis, A., Menown, I.B.A., Trovik, T., Kellerth, Thomas, Kalinauskas, G., Mogensen, Lone Juul Hune, Nielsen, P.H., Niemelä, M., Lassen, J.F., Oldroyd, K., Berg, Geoffrey, Stradins, P., Walsh, S.J., Graham, A.N.J., Endresen, P.C., Fröbert, O., Trivedi, U., Anttila, Vesa, Hildick-Smith, D., Thuesen, L., Christiansen, E.H., Lindsay, M., Eskola, M., Romppanen, H., Kellerth, Tholmas, Jensen, L.O., Linder, R.B.A., Pentikainen, M., Hervold, A., Banning, A., Zaman, A., Cotton, J., Eriksen, E., Margus, S., Mogensen, Lone J.H., Kervinen, K., Berg, Geoff, Hanratty, C.G., Kumsars, I., Steigen, T.K., Graham, A.N., Corbascio, M., Kajander, O., Hartikainen, J., Anttila, Ves, 2020. Percutaneous coronary angioplasty versus coronary artery bypass grafting in the treatment of unprotected left main stenosis: updated 5-year outcomes from the randomised, non-inferiority NOBLE trial. Lancet 395, 191–199.
Hu, F., Tu, S., Cai, W., Zheng, H., Xiao, L., Chen, H., Qiu, C., Xiong, C., Yao, Y., Jiang, Q., Chen, L., 2017. Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Unprotected Left Main Coronary Artery Stenosis. Int J Clin Exp Med 10, 4969–4985.
Husebye, E.S., 2005. Autoantibodies to a NR2A peptide of the glutamate/NMDA receptor in sera of patients with systemic lupus erythematosus. Ann. Rheum. Dis. 64, 1210–1213.
Jeong, D., Lee, Y.T., Chung, S.R., Jeong, J.H., Kim, W.S., Sung, K., Park, P.W., 2013. Revascularization in left main coronary artery disease: Comparison of off-pump coronary artery bypass grafting vs percutaneous coronary intervention. Eur. J. Cardio-thoracic Surg. 44, 718–724.
Jeong, H.S., Cho, J.Y., Kim, E.J., Yu, C.W., Ahn, C.M., Park, J.H., Hong, S.J., Lim, D.S., 2013. Comparison of clinical outcomes between first-generation and second-generation drug-eluting stents in type 2 diabetic patients. Coron. Artery Dis. 24, 676–683.
Kampylafka, E.I., Alexopoulos, H., Kosmidis, M.L., Panagiotakos, D.B., Vlachoyiannopoulos, P.G., Dalakas, M.C., Moutsopoulos, H.M., Tzioufas, A.G., 2013. Incidence and Prevalence of Major Central Nervous System Involvement in Systemic Lupus Erythematosus: A 3-Year Prospective Study of 370 Patients. PLoS One 8, e55843.
Kano, O., Arasaki, K., Ikeda, K., Aoyagi, J., Shiraishi, H., Motomura, M., Iwasaki, Y., 2009. Limbic encephalitis associated with systemic lupus erythematosus. Lupus 18, 1316–1319.
Kelley, B.P., Corrigan, J.J., Patel, S.C., Griffith, B.D., 2018. Neuropsychiatric Lupus with Antibody-Mediated Striatal Encephalitis. AJNR. Am. J. Neuroradiol. 39, 2263–2269.
Kowal, C., DeGiorgio, L.A., Nakaoka, T., Hetherington, H., Huerta, P.T., Diamond, B., Volpe, B.T., 2004. Cognition and Immunity. Immunity 21, 179–188.
Lang, K., Prüss, H., 2017. Frequencies of neuronal autoantibodies in healthy controls. Neurol. - Neuroimmunol. Neuroinflammation 4, e386.
Levite, M., 2014a. Glutamate receptor antibodies in neurological diseases: anti-AMPA-GluR3 antibodies, anti-NMDA-NR1 antibodies, anti-NMDA-NR2A/B antibodies, anti-mGluR1 antibodies or anti-mGluR5 antibodies are present in subpopulations of patients with either: epilepsy, en. J Neural Transm 121, 1029–1075.
Levite, M., 2014b. GLUTAMATE RECEPTOR ANTIBODIES IN NEUROLOGICAL DISEASES: Anti-AMPA-GluR3 antibodies, Anti-NMDA-NR1 antibodies, Anti-NMDA-NR2A/B antibodies, Anti-mGluR1 antibodies or Anti-mGluR5 antibodies are present in subpopulations of patients with either: Epilepsy, En. J. Neural Transm. 121, 1029–1075.
Li, H.R., Hsu, C.P., Sung, S.H., Shih, C.C., Lin, S.J., Chan, W.L., Wu, C.H., Lu, T.M., 2017. Percutaneous coronary intervention versus coronary artery bypass grafting in patients with diabetic nephropathy and left main coronary artery disease. Acta Cardiol. Sin. 33, 119–126.
Li, R., Wang, Y., Wu, X., Wang, J., Wei, W., Li, X., 2022. Neuropsychiatric lupus erythematosus with neurogenic pulmonary edema and anti-$α$-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor limbic encephalitis: a case report. BMC Neurol. 22, 222.
Liu, Y., Tu, Z., Zhang, X., Du, K., Xie, Z., Lin, Z., 2022. Pathogenesis and treatment of neuropsychiatric systemic lupus erythematosus: A review. Front. Cell Dev. Biol. 10.
Manorenj, S., Shaik, R.S., 2021. Chronic psychiatric illness masquerading as bipolar disorder in a family secondary to familial systemic lupus erythematosus with limbic encephalitis. Indian J. Psychiatry 63, 517–519.
Moroni, F., Beneduce, A., Giustino, G., Briede, I., Park, S.J., Daemen, J., Morice, M.C., Nakamura, S., Meliga, E., Cerrato, E., Makkar, R.R., D’ascenzo, F., Lucarelli, C., Capranzano, P., Tchetche, D., Templin, C., Kirtane, A., Buzman, P., Alfieri, O., Valgimigli, M., Mehran, R., Colombo, A., Montorfano, M., Chieffo, A., 2022. Sex Differences in Outcomes After Percutaneous Coronary Intervention or Coronary Artery Bypass Graft for Left Main Disease: From the DELTA Registries. J. Am. Heart Assoc. 11.
Muñoz, D., Hernández, D.L., Giraldo, N., 2017. Limbic encephalitis with phenotypic NMDA receptor antibodies in patients with de novo diagnosis of Systemic Lupus Erythematosus. Case report. Colomb. J. Anesthesiol. 45, 59–65.
Naganuma, T., Chieffo, A., Meliga, E., Capodanno, D., Park, S.J., Onuma, Y., Valgimigli, M., Jegere, S., Makkar, R.R., Palacios, I.F., Costopoulos, C., Kim, Y.H., Buszman, P.P., Chakravarty, T., Sheiban, I., Mehran, R., Naber, C., Margey, R., Agnihotri, A., Marra, S., Capranzano, P., Leon, M.B., Moses, J.W., Fajadet, J., Lefevre, T., Morice, M.C., Erglis, A., Tamburino, C., Alfieri, O., Serruys, P.W., Colombo, A., 2013. Long-term clinical outcomes after percutaneous coronary intervention for ostial/mid-shaft lesions versus distal bifurcation lesions in unprotected left main coronary artery: The DELTA Registry (Drug-Eluting Stent for Left Main Coronary Artery Disease): A . JACC Cardiovasc. Interv. 6, 1242–1249.
Naganuma, T., Chieffo, A., Meliga, E., Capodanno, D., Park, S.J., Onuma, Y., Valgimigli, M., Jegere, S., Makkar, R.R., Palacios, I.F., Costopoulos, C., Kim, Y.H., Buszman, P.P., Chakravarty, T., Sheiban, I., Mehran, R., Naber, C., Margey, R., Agnihotri, A., Marra, S., Capranzano, P., Leon, M.B., Moses, J.W., Fajadet, J., Lefevre, T., Morice, M.C., Erglis, A., Tamburino, C., Alfieri, O., Serruys, P.W., Colombo, A., 2014. Long-term clinical outcomes after percutaneous coronary intervention versus coronary artery bypass grafting for ostial/midshaft lesions in unprotected left main coronary artery from the DELTA registry: A multicenter registry evaluating percutaneous corona. JACC Cardiovasc. Interv. 7, 354–361.
Ogawa, E., Nagai, T., Sakuma, Y., Arinuma, Y., Hirohata, S., 2016. Association of antibodies to the NR1 subunit of N -methyl- D -aspartate receptors with neuropsychiatric systemic lupus erythematosus. Mod. Rheumatol. 26, 377–383.
Omdal, R., Brokstad, K., Waterloo, K., Koldingsnes, W., Jonsson, R., Mellgren, S.I., 2005. Neuropsychiatric disturbances in SLE are associated with antibodies against NMDA receptors. Eur. J. Neurol. 12, 392–398.
Ota, Y., Srinivasan, A., Capizzano, A.A., Bapuraj, J.R., Kim, J., Kurokawa, R., Baba, A., Moritani, T., 2022. Central Nervous System Systemic Lupus Erythematosus: Pathophysiologic, Clinical, and Imaging Features. RadioGraphics 42, 212–232.
Otsuka, F., Yahagi, K., Sakakura, K., Virmani, R., 2013. Why is the mammary artery so special and what protects it from atherosclerosis? Ann Cardiothorac Surg 2, 519–526.
Palmerini, T., Biondi-Zoccai, G., Reggiani, L.B., Sangiorgi, D., Alessi, L., De Servi, S., Branzi, A., Stone, G.W., 2012. Risk of stroke with coronary artery bypass graft surgery compared with percutaneous coronary intervention. J. Am. Coll. Cardiol. 60, 798–805.
Papadopoulos, K., Lekakis, I., Nicolaides, E., 2017. Outcomes of coronary artery bypass grafting versus percutaneous coronary intervention with second-generation drug-eluting stents for patients with multivessel and unprotected left main coronary artery disease. SAGE Open Med. 5, 205031211668770.
Park, S., Park, S.J., Park, D.W., 2022. Percutaneous Coronary Intervention for Left Main Coronary Artery Disease: Present Status and Future Perspectives. JACC Asia 2, 119–138.
Raventhiranathan, N., Hussien, A.R., Mirchia, K., Swarnkar, A., Mangla, R., 2022. Striatal dominant lupus encephalitis-Is it vasculitis or an autoimmune process? Literature review & new case report with vessel wall imaging. Radiol. case reports.
Sato, S., Temmoku, J., Fujita, Y., Yashiro-Furuya, M., Matsuoka, N., Asano, T., Kobayashi, H., Watanabe, H., Migita, K., 2020. Autoantibodies associated with neuropsychiatric systemic lupus erythematosus: the quest for symptom-specific biomarkers. FUKUSHIMA J. Med. Sci. 66, 1–9.
Sechi, E., Flanagan, E.P., 2021. Antibody-Mediated Autoimmune Diseases of the CNS: Challenges and Approaches to Diagnosis and Management. Front. Neurol. 12.
Selcuk, H., Albayram, S., Ulus, S., Hasiloglu, Z., Kizilkilic, O., 2011. Limbic Encephalitis in Association with Systemic Lupus Erythematosus: A Case Report. NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY 48, 88–91.
Shu, Y., Qiu, W., Zheng, J., Sun, X., Yin, J., Yang, X., Yue, X., Chen, C., Deng, Z., Li, S., Yang, Y., Peng, F., Lu, Z., Hu, X., Petersen, F., Yu, X., 2019. HLA class II allele DRB1*16:02 is associated with anti-NMDAR encephalitis. J. Neurol. Neurosurg. Psychiatry 90, 652–658.
Stone, G.W., Sabik, J.F., Serruys, P.W., Simonton, C.A., Généreux, P., Puskas, J., Kandzari, D.E., Morice, M.-C., Lembo, N., Brown, W.M., Taggart, D.P., Banning, A., Merkely, B., Horkay, F., Boonstra, P.W., van Boven, A.J., Ungi, I., Bogáts, G., Mansour, S., Noiseux, N., Sabaté, M., Pomar, J., Hickey, M., Gershlick, A., Buszman, P., Bochenek, A., Schampaert, E., Pagé, P., Dressler, O., Kosmidou, I., Mehran, R., Pocock, S.J., Kappetein, A.P., 2016. Everolimus-Eluting Stents or Bypass Surgery for Left Main Coronary Artery Disease. N. Engl. J. Med. 375, 2223–2235.
Stubgen, J.P., Stübgen, J.P., Stubgen, J.P., Stübgen, J.P., 1998. Nervous system lupus mimics limbic encephalitis. Lupus 7, 557–560.
Sugi, S., Kaieda, S., Irie, K.-I., Ida, H., 2018. Limbic Encephalitis in Association with Systemic Lupus Erythematosus. Intern. Med. 57, 3059.
Tsuchiya, H., Iwasaki, Y., Shoda, H., Takahashi, Y., Fujio, K., 2021. Limbic encephalitis in a patient with systemic lupus erythematosus successfully treated with high-dose glucocorticoids and intravenous cyclophosphamide therapy: the potential pathogenicity of anti-glutamate receptor antibodies. Mod. Rheumatol. case reports.
Vivaldo, J.F., de Amorim, J.C., Julio, P.R., de Oliveira, R.J., Appenzeller, S., 2018. Definition of NPSLE: Does the ACR Nomenclature Still Hold? Front. Med. 5.
Wańha, W., Bil, J., Kołodziejczak, M., Kowalówka, A., Kowalewski, M., Hudziak, D., Gocoł, R., Januszek, R., Figatowski, T., Milewski, M., Tomasiewicz, B., Kübler, P., Hrymniak, B., Desperak, P., Kuźma, Ł., Milewski, K., Góra, B., Łoś, A., Kulczycki, J., Włodarczak, A., Skorupski, W., Grygier, M., Lesiak, M., D’Ascenzo, F., Andres, M., Kleczynski, P., Litwinowicz, R., Borin, A., Smolka, G., Reczuch, K., Gruchała, M., Gil, R.J., Jaguszewski, M., Bartuś, K., Suwalski, P., Dobrzycki, S., Dudek, D., Bartuś, S., Ga̧sior, M., Ochała, A., Lansky, A.J., Deja, M., Legutko, J., Kedhi, E., Wojakowski, W., 2022. Percutaneous Coronary Intervention vs. Coronary Artery Bypass Grafting for Treating In-Stent Restenosis in Unprotected-Left Main: LM-DRAGON-Registry. Front. Cardiovasc. Med. 9.
Wu, Y.-Y., Feng, Y., Huang, Y., Zhang, J.-W., 2016. Anti-N-Methyl-D-Aspartate Receptor Encephalitis in a Patient with Systemic Lupus Erythematosus. J. Clin. Neurol. 12, 502.
Yamaguchi, Y., Wada, M., Kurita, K., Takahashi, Y., Kato, T., 2012. Case of acute limbic encephalitis associated with SLE accompanied with anti-glutamate receptor antibodies. Rinsho Shinkeigaku 52, 545–550.
Yu, X.P., Wu, C.Y., Ren, X.J., Yuan, F., Song, X.T., Luo, Y.W., He, J.Q., Gao, Y.C., Huang, F.J., Gu, C.X., Sun, L.Z., Lyu, S.Z., Chen, F., 2016. Very long-term outcomes and predictors of percutaneous coronary intervention with drug-eluting stents versus coronary artery bypass grafting for patients with unprotected left main coronary artery disease. Chin. Med. J. (Engl). 129, 763–770.
Zhang, S., Yang, Y., Long, T., Li, Z., 2021. Systemic lupus erythematosus associated with recurrent anti-NMDA receptor encephalitis during pregnancy. Arch. Womens. Ment. Health 24, 525–528.
Zhao, J., Wang, C., Xu, X., Zhang, Y., Ren, H., Ren, Z., Li, G., Zhang, J., Guan, H., 2019. Coexistence of Autoimmune Encephalitis and Other Systemic Autoimmune Diseases. Front. Neurol. 10.
Zheng, Z., Xu, B., Zhang, H., Guan, C., Xian, Y., Zhao, Y., Fan, H., Yang, Y., Wang, W., Gao, R., Hu, S., 2016. Coronary Artery Bypass Graft Surgery and Percutaneous Coronary Interventions in Patients With Unprotected Left Main Coronary Artery Disease. JACC Cardiovasc. Interv. 9, 1102–1111.
Unduhan
Diterbitkan
Terbitan
Bagian
Kategori
Lisensi
Hak Cipta (c) 2023 Fanny Liana Halim, Nila
Artikel ini berlisensi Creative Commons Attribution 4.0 International License.
