Surgical excision of sebaceous gland carcinoma of the eyelid: a comprehensive case study
Sebaceous gland carcinoma
DOI:
https://doi.org/10.59747/smjidisurabaya.v2i2.64Kata Kunci:
Sebaceous Carcinoma, Cancer, Adenocarcinoma, Eyelid NeoplasmAbstrak
Background: Sebaceous gland carcinoma is a rare but aggressive malignancy with a propensity for metastasis. Delayed diagnosis contributed to increased mortality rates. This carcinoma is primarily found in the periocular region and originates from various sebaceous glands, posing diagnostic challenges. Objective: to provide a detailed clinical description and management approach for sebaceous gland carcinoma treated with surgical intervention. Case: A 59-year-old male presented with a lesion on his right lower eyelid, accompanied by itching and intermittent discharge. Clinical examination revealed a cauliflower-like lesion on the right lower eyelid. An excisional biopsy confirmed the diagnosis of sebaceous gland carcinoma. Surgical intervention involved wide excision, preserving adjacent structures. Postoperative care included prophylactic measures for dry eye syndrome and antibiotic therapy to prevent infection. Postoperative follow-up demonstrated satisfactory outcomes, with resolution of symptoms and no signs of recurrence. Discussion: Sebaceous gland carcinoma can present with various manifestations. Surgical excision is the standard treatment, with adjuvant therapies considered for advanced cases. Dry eye syndrome, ectropion, and entropion are common post-surgical complications, particularly following procedures involving the eyelids as observed in this case. These conditions may resolve spontaneously with appropriate management of the underlying causative factors. Meanwhile, symptomatic relief can be achieved through ocular lubrication. Conclusion: This case report emphasizes the importance of timely diagnosis, precise surgery, and thorough postoperative care for sebaceous gland carcinoma. While acknowledging the limitations of this study, further research is necessary to improve therapeutic strategies for this challenging malignancy.
Referensi
Adachi, A., Oike, T., Tamura, M., Ota, N., Ohno, T., 2022. Radiotherapy With Hydrogen Peroxide-Soaked Gauze for Preauricular Sebaceous Carcinoma. Cureus 14, 5–9.
Adamski, W.Z., Maciejewski, J., Adamska, K., Marszałek, A., Rospond-Kubiak, I., 2021. The prevalence of various eyelid skin lesions in a single-centre observation study. Postep. Dermatologii i Alergol. 38, 804–807.
Ambrosino, M., Muzio, L. Lo, 2021. Sebaceous Carcinoma of The Lip: Report of a Case and Literature Review 1–8.
Aulia, D., Irawan, E., 2022. Sebaceous carcinoma of lacrimal gland with endophthalmitis. Int. J. Res. Med. Sci. 10, 2936.
Aung, P.P., Batrani, M., Mirzabeigi, M., Goldberg, L.J., 2014. Extracellular sebaceous carcinoma in situ: report of three cases and review of the literature. J. Cutan. Pathol. 41, 592–596.
Dasgupta, T., Wilson, L.D., Yu, J.B., 2009. A retrospective review of 1349 cases of sebaceous carcinoma. Cancer 115, 158–165.
Di Cosola, M., Spirito, F., Ambrosino, M., Somma, P., Santarelli, A., Staibano, S., Lo Muzio, L., 2022. Sebaceous carcinoma of the lip: a case report and review of the literature. J. Med. Case Rep. 16.
Ferreira, I., Wiedemeyer, K., Demetter, P., Adams, D.J., Arends, M.J., Brenn, T., 2019. Update on the pathology, genetics and somatic landscape of sebaceous tumours. Histopathology 76, 640–649.
Gall, R., Ortiz-Perez, S., 2023. Sebaceous gland carcinoma [WWW Document]. StatPearls [Internet].
Helmi, H.A., Alsarhani, W., Alkatan, H.M., Al-Rikabi, A.C., Al-Faky, Y.H., 2020. Sebaceous gland carcinoma with misleading clinical appearance: a case report of an eyelid lesion. Am. J. Case Rep. 21, 1–4.
Ito, T., Hashimoto, H., Tanaka, Y., Tanegashima, K., Murata, M., Ichiki, T., Iwasaki, T., Oda, Y., Kaku-Ito, Y., 2022. TROP2 Expression in Sebaceous and Sweat Gland Carcinoma. J. Clin. Med. 11.
Jodai, Y., Hamada, S., Yamada, M., Masuda, Y., Anai, M., Jodai, T., Tomita, Y., Saeki, S., Ichiyasu, H., Sakagami, T., 2023. Primary lung sebaceous carcinoma successfully treated with radiotherapy and pembrolizumab: A case report. Thorac. Cancer 14, 331–335.
Kaliki, S., Ayyar, A., Dave, T. V., Ali, M.J., Mishra, D.K., Naik, M.N., 2015. Sebaceous gland carcinoma of the eyelid: Clinicopathological features and outcome in Asian Indians. Eye 29, 958–963.
Kiran, S., Khan, F.A.A., Ali, H., Kumar, S., Sami, W., Khursheed, R.M., 2022. Surgical Correction of Ectropion: Comparison Between Full Thickness Skin Grafts and Local Flaps. Pakistan Armed Forces Med. J. 72, 961–965.
Lee, J.H., Woo, S.S., Shin, S.H., Kim, H.J., Kim, J.H., Kim, S.H., Suh, I.S., 2021. Upper eyelid reconstruction using a combination of a nasal septal chondromucosal graft and a fricke flap: A case report. Arch. Craniofacial Surg. 22, 204–208.
Mangan, M.S., Ozcan, Z., Aksoy, N.O., 2021. Clinical time course of the neglected giant sebaceous gland carcinoma. Rom. J. Ophthalmol. 65, 290–292.
Niinimäki, P., Siuko, M., Tynninen, O., Kivelä, T.T., Uusitalo, M., 2021. Sebaceous carcinoma of the eyelid: 21-year experience in a Nordic country. Acta Ophthalmol. 99, 181–186.
Sargen, M.R., Starrett, G.J., Engels, E.A., Cahoon, E.K., Tucker, M.A., Goldstein, A.M., 2021. Sebaceous carcinoma epidemiology and genetics: Emerging concepts and clinical implications for screening, prevention, and treatment. Clin Cancer Res 27, 389–393.
Syed, N.., Berry, J.L., Heegaard, S., Kramer, T.R., Lee, V., Raparia, K., Skalet, A.., 2022. 2021-2022 Basic and Clinical Science Course, Section 4: Ophthalmic pathology and intraocular tumors. In: Rapuano, C.J., Stout, J.T., McCannel, C.. (Eds.), 2021-2022 Basic and Clinical Science Course. American Academy of Ophthalmology, San Fransisco, pp. 254–256.
Taoufik, H., Boujguenna, I., Benlaassel, O., Belbachir, A., Rais, H., Benchamkha, Y., Hocar, O., Amal, S., 2022. Metastatic extraocular sebaceous carcinoma: a case report and review of literature. Res. Sq. 1–8.
Tripathi, R., Chen, Z., Li, L., Bordeaux, J.S., 2016. Incidence and survival of sebaceous carcinoma in the United States. J. Am. Acad. Dermatol. 75, 1210–1215.
Vehof, J., Snieder, H., Jansonius, N., Hammond, C.J., 2021. Prevalence and risk factors of dry eye in 79,866 participants of the population-based Lifelines cohort study in the Netherlands. Ocul. Surf. 19.
Vissers, G., Corthouts, J., Van Haverbeke, C., Declercq, S., Mertens, M., 2022. Misdiagnosis of sebaceous carcinoma. Acta Chir. Belg. 122, 127–132.
Wang, F., Wang, X.Y., Jiang, X., 2022. Clinical Features and Prognosis of Young and Middle-Aged Adults With Skin Sebaceous Adenocarcinoma. Dermatologic Surg. 48, 797–801.
Xu, Y., Li, F., Jia, R., Fan, X., 2018. Updates on the clinical diagnosis and management of ocular sebaceous carcinoma: A brief review of the literature. Onco. Targets. Ther. 11, 3713–3720.
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